Zika Virus Can Infect And Replicate In Cells Without Killing Them; It’s Also Unique In Its Ability To Cross Placental Barrier

By | November 11, 2018

Zika Virus Can Infect And Replicate In Cells Without Killing Them; It's Also Unique In Its Ability To Cross Placental Barrier

Zika’s resurgence has spurred an uptick in both public fear of the virus and research into how it functions. A team of researchers from Emory University dove into the pathology of the virus to determine precisely how it passes through the placenta of a pregnant woman and puts her baby at risk. The results showed that Zika can infect and replicate in immune cells from the placenta without killing them — allowing the virus to move on to infect the developing brain of a growing fetus.

“Our results substantiate the limited evidence from pathology case reports,” said Dr. Mehul Suthar, the study’s senior author and an assistant professor of pediatrics at Emory University School of Medicine, in a press release. “It was known that the virus was getting into the placenta. But little was known about where the virus was replicating and in what cell type.”

The team, led by Suthar and pediatric infectious disease specialist Dr. Rana Chakraborty, found that had the ability to infect Hofbauer cells. A type of macrophage, these cells function by swallowing up smaller cells and particles. In addition,  could infect a type of placental cell called cytotrophoblasts — though it could not invade these cells as readily, and could only do so after a couple days.

The researchers derived the cells for the study from full-term placentas taken from healthy volunteers. They noted that in some women the placenta may be more vulnerable to than in others, since the level of viral spread varied significantly from donor to donor.

“Not every pregnant woman who is infected by Zika transmits the virus to her fetus,” Suthar explained. “Host genetics and non-viral factors, including nutrition and microbiota, as well as timing may be influencing infectivity. A better understanding of these factors could allow the design of preventative measures, and eventually antiviral therapies.”

Suthar said  may be unique in its ability to cross the placental barrier and infect a fetus’ cells, compared to other related viruses like dengue virus and West Nile virus.

Hofbauer cells are fetally derived, which is unique among maternally derived immune cells found in the placenta. Previous studies have found they may be less prone to inflammatory responses than other immune cells. Still, Suthar’s team found signs of antiviral and inflammatory response in the cells, and intend to continue their work in investigating their immunology.

“We need to answer questions such as: What are the receptors that allow the virus to enter Hofbauer cells?” Suthar said. “Do these cells change in their immune status during the different phases of pregnancy?”

Source: Quicke K, Bowen J, Rimawi B, Pulendran B, Schinazi R, Chakraborty R, et al. How  Infects the Placenta. Cell Host & Microbe. 2016.

We picked linked items based on the quality of products, and list the pros and cons of each to help you determine which will work best for you. We partner with some of the companies that sell these products, which means we and our partners may receive a portion of revenues if you make a purchase using a link(s) above.

MUST READ Medical Dictionary :

Other amazing related Dreams you might like:

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

© 2018 Medical Dictionary All rights reserved.

Dream Dictionary | Metroeve Style | Fashion Inspiration & Trends

PRIVACY POLICY | COOKIES POLICY | TERMS OF USE

Disclaimer Medical Dictionary is for informational purposes and should not be considered medical advice, diagnosis or treatment recommendation. Read more